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In an attempt to prevent the Uchiha Massacre, Shisui Uchiha tried to use his Mangekyo Sharingan to stop Danzo, but Danzo stole his right eye, and later commandeered ten Sharingan from the victims of the massacre. He then implanted Shisui's right eye into his right eye socket and had the ten Sharingan embedded into his arm, with some help from Orochimaru.

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