She retired after the war and gave the position of Hokage to Kakashi. Shortly after, she started research on the White Zetsu/Hashirama's cells in order to create artificial arms for both Naruto and Sasuke, although only Naruto chose to receive it. Two years after the Fourth Shinobi World War, Tsunade assisted hundreds of Konoha citizens in evacuating to an underground shelter to protect them from falling meteors along with Shizune. She later hears the worldwide announcement about the moon crisis being averted amongst many other villagers. She also later attended Naruto and Hinata's wedding, as seen was seen attending with Kakashi, Shizune, and Yamato. During the Epilogue, she is also present, attending a "Kage reunion" held at Iwagakure, which is being held there because of the Third Tsuchikage's advanced age.